|
Detoxification and
Drainage
A Theoretical and
Practical Approach
The Physiology of
Detoxification
In the previous chapter we saw that the body is
esposed to a wide variety toxins present in the air, water, soil and
food. The body has several inherent defense mechanisms and membrane
barriers to prevent the absorption and distribution of the toxin
when the intoxication has occurred. Once inside the body, the
internal defense system, or Basic Bioregulatory System will be
mobilized in order to eliminate the toxin or at least try to
compensate for it.
In this chapter, We
will look at the way the body deals with these toxins. Before a
toxin can have a detrimental effect on the body, it needs to reach
the target organ or cell. In principle four steps are necessary for
this:
-
Absorption
-
Transport
-
Metabolism
-
Distribution and storage
-
Elimination
Toxicokinetics
studies the absorption, distribution, elimination, metabolism and/or
clearance that take place in the body after exposure to the toxin.
Toxicodynamics on the other hand studies the biochemical and
physiological effects of drugs and toxicants and determines their
mechanism of action. Toxicokinetics can also be seen in the diagram
below.
1 Absorption
Toxins can enter the
body through all the surfaces which are in contact with the outside
world. These comprise the skin, the mucous membranes and also the
gastrointestinal tract. In general, the absorption over the
respiratory mucosa is the quickest, whereas it is the slowest over
the dermal route. The overall entry depends on the amount of toxins
present, but also on the saturability of the transport process.
The mucosal surfaces
have several barriers which will prevent toxins from entering the
body, such as a mucosal barrier, the physical presence of symbiotic
bacteria as well as the so-called tight junction. The skin also has
barriers in the form of a certain level of pH, etc.
2 Transport
Once the toxicant is
absorbed into the body it moves around in two ways, either by bulk
transfer via the blood or lymph, but also locally through
diffusional transfer over short distances. The path which a toxin
takes after absorption is illustrated in Fig.II,2.
During absorption,
distribution and elimination, a toxin will encounter various cell
membranes before interacting with the target tissue. These membrane
barriers will differ from relatively thick areas of the skin to
relatively thin lung membranes, in all cases though the composition
is relatively similar.
The cell membrane can
be seen as a lipid matrix. If contains both phospholipids
(hydrophobic) portions as well as hydrophilic heads. Intra- and
extracellular proteins transverse the membrane.
This will differ from
organ to organ. The myelin in the brain consists of 100% lipid
bilayer whereas mitochondria have only a 40% lipid bilayer. This, of
course has implication for the distribution of fat soluble toxins.
Depending on the fat solubility of the toxin, it will thus
transverse the cell membrane. Many of the proteins which tranverse
the membrane are active in transport of toxins over the cell
membranes.
The distribution of
the absorbed toxin will depend on various factors, such as
physiological factors, but also the phyusiochemincal properties of
the drug. This process is thus a REVERSIBLE movement of the toxicant
between the blood and tissues and between the extracellular and
intracellular compartment. The velocity at which this movement is
reversible becomes important when we address the mobilization and
drainage of toxins later on.
Factors which can
complicate the distribution of a toxin can be the following:
-
Perfusion of the organ
The well perfused
tissues include the liver, kidneys and brain; whereas the low
perfused tissues include the bone and fat tissue where there is slow
elimination from these tissues.
-
Protein Binding
There also may be
significant protein binding which could affect the delivery of the
drug to the tissues and vice versa. Especially binding of toxins to
the matrix structures may trap these toxins there for years and
prevent elimination.
Protein binding also
plays a very important role in the transport of toxins. There are
many plasma proteins involved in such a transport, but mostly
involved are albumin, alpha-acid-glycoprotein, the lipoproteins, and
globulins.
The lipoproteins,
such as HDL,LDL and VLDL are very important here, as so many toxins
are lipophilic, and therefore they will carry a number of toxins.
Iron and copper will again be carried by the metal binding
globulins, transferring and cereluplasmin.
3 Distribution and
Storage
Plasma protein
binding is not selective and toxints can thus compete with each
other and even with endogenous substances for binding. Covalent
binding to the protein forms a minor part, but the dissociation I
extremely difficult and the carrier molecule is changed, and may
eventually play a role in carcinogenesis.
Noncovalent binding
is more common. The toxin can dissociate easier from this bond.
However, in some cases the bond may be so strong that the toxin
remains bound for weeks, months or years. Certain metals have high
association constants and their dissociation is extremely slow.
If the affinity for
an organ is large, the toxin will accumulate or form a depot for
years. In general, lipid insoluble toxicants stay in the plasma and
interstitial fluids, while lipid soluble contaminants reach all
compartments, and may accumulate in fat.
Some toxins have
specific affinity for certain tissues. Tetracyclines have a high
affinity for the calcium containing tissues, which is seen in the
discoloration of teeth if it is given under the age of 14 years.
Similarly, the anti-malarial, chloroquine has an affinity for the
melanin, and can be taken up by tissues like the retina, causin a
retinitis. This drug is often used in lupus and other connective
tissue diseases, which makes an ophthalmic check up every six months
mandatory.
Bone will also
concentrate certain toxicants such as lead where a sudden loss of
bone can lead to acute release of the toxin and have dire
consequences, especially after menopause when there may be a sudden
bone loss.
This will be
discussed later when we look at the indeal rates of detoxification.
Lipophilic
pesticides, such as the organochlorines and PCB’s can be expected to
accumulate in fat tissues.
The affinity of
metals to SH groups have also been addressed in the previous
chapters.
The binding of these
metals to the numerous thiol groups in the extracellular matrix is
of special concern.
Certain areas will be
naturally less penetrable to toxins. The brain, which is protected
by the blood brain barrier, is such an example. Disease processes
such as meningitis and other inflammatory or infective processes can
disrupt this barrier and thus cause toxins to enter the brain
tissue.
Other tissue blood
barriers include the prostate/blood barrier and the testis/blood
barrier.
Unfortunately, other
than what is generally believed, the placenta is a poor barrier and
the fetus is thus exposed to all the toxins to which the mother is
exposed. This has been seen in fat tissue biopsies which were
performed on newborns and found numerous toxins such as PCB’s,
dioxin and others in the tissues. We need thus to assume in today’s
environmental pollution, that our newborns are already contaminated
with toxins.
4 Metabolism of
Toxins
One of the most
important determinants of the persistence of toxins in the body is
the extent to which they can be metabolized and excreted.
Several families of
metabolic enzymes are active in metabolism of endogenous and
exogenous toxins.
These include one of
the most important, the P450 system, but also the flavin containing
monooxidases(FMO’s), the alcohol and aldehyde dehydrogenases, amine
oxidases cyclooxygenases, reductases, hydrolases and the conjugating
enzymes such as the methyltransferases as well as the glutathione
transferases to name a few.
Most of the
metabolism takes place in the liver, and as most of the toxins
entering the body are lipophilic, they need to become water soluble
for excretion. After entrance to the liver and other organs,
xenobiotics may undergo two phases of metabolism.
4.1 Phase I
Reactions
Phase I metabolism
involves mainly the CYP(P450) system, the FMO’s and the hydrolases.
Following the addition of a polar group, conjugating enzymes
typically add more constituents, such as sugars, sulfatesor amino
acids which make the compound more water soluble.
In this process,
however sometimes more toxic intermediate metabolites are formed,
these then will have to be detoxified again. These intermediate
metabolites are likely to react with nudear parts of macromolecules
unless they are further detoxified. An example is the breakdown of
alcohol to acetaldehyde, which is much more toxic that the alcohol.
The CYP system or
P450 plays a very important role in the phase I reactions. The CYP’s
which constitutes the carbon monoxide-binding pigment of the liver
microsomes are heme proteins. A nomenclature has been developed for
the different types and isoforms.
Although mammals are
known to have 18 CYP families, only three are responsible for
xenobiotic metabolism. The remaining are involved in steroid hormone
production. They are classified according to the gene, subfamily and
lastly the isoform (Arabic numeral, letter, Arabic numeral).
Thus CYP 3 A 4 is
responsible for the metabolism of many drugs as well as endogenous
toxins and exogenous toxins.
Its activity can also
be influenced by a host of drugs and chemicals, and it can either be
induced, which will have the result that certain drugs are broken
down too quickly, e.g., warfarin, whereas grapefruit juice in large
quantities is known in fact to damage this system irrevocably and
thus may lead to an accumulation of drugs.
The Phase I
detoxifying pathway takes care of environmental toxins such as
pesticides, pollutants and food additives as well as drugs and
alcohol. The end products of uur own metabolism are also processed
here for excretion. Fat soluble toxins are changed by way of
oxidation, reduction and hydrolysis to make them more water soluble
for excretion via the bile and the kidney.
It is important to
note that these enzymes need certain co-factors to fulfill their
action. These are trace elements, vitamins, amino acids and
substances like NADH.
Phase I produces
significant amounts of free radicals during this detoxification
processs, and if the antioxidant status of the patient is not
adequate tissues damage may occur if the P450 is overloaded, or
induced. Some substances, such as caffeine, alcohol, certain drugs,
dioxin and organophosphates (used as pesticides), and paint fumes
can induce this pathway. Sometimes intermediate substances like the
acetaldehyde formed during the metabolism of certain toxins, like
alcohol, can be more toxic to the body than the original substance.
Certain people, called fast acetylators, will then be more prone to
damage of the liver, as the toxin is fast metabolized to this
dangerous intermediate, and then the process is slow again. These
individuals are at higher risk for liver damage during ingestion of
toxins which will use the alcohol dehydrogenase pathway to be
detoxified, for example when paracetamol overdose occurs.
4.2 Phase II
Reactions
The Phase II pathway
or conjugation pathway uses substances rich in sulfhydryl groups to
metabolize toxins. A number of these substances, like cysteine and
taurine as well as glutathione which are formed from glycine,
glutamine and cysteine under influence of a selenium dependent
enzyme, also act as free radical scavengers and heavy metal
chelators. During conjugation of toxins they are lost to the body
forever, as they are excreted with the toxin, whereas as free
radicals they can be regenerated. Some substances will only use
phase I or phase II to be detoxified, others will use both. It is
thus clear, that if the phase II pathway is overloaded, the free
radical scavenging ability will be given up in favor of the
conjugation function and further damage to the liver parenchyma may
occur. Also if the patient is deficient in selenium for instance,
glutathione production will be impaired, with the resultant of
toxicity and free radical damage.
5 Elimination
After the toxins have
gone through these two phases, they are ready to be eliminated.
However, if the intermediary toxin is not broken down, or the toxin
load is too high there will be bioaccumulation of the toxin.
The ability to
detoxify and eliminate toxins is paramount to the maintenance of
health in an organism.
For unicellular
organisms a simple process of diffusion is enough to eliminate
toxins, however, multicellular organisms, especially if there has
been an increase in complexity, needs to find other ways to
eliminate toxins.
With an increase in
complexity, organisms have developed an increase in size, a decrease
in surface area to body mass ratio, compartmentalization of cells
and organs, as well as an increase in lipid content. Together with
the fact that organisms neeed to protect themselves from the
environment with barriers such as scales and skin, means that there
is less possibility for toxins to diffuse out of the body. This was
solved, by developing specialized methods of metabolism for toxins
and specialized routes of elimination. We have thus major and minor
elimination routes.
The major routes
involve the liver, the kidneys, the mucous membranes and the lungs
as well as the skin, whilst the minor routes involve the saliva,
sweat, milk, hair, and secretion from reproductive organs.
To eliminate the
toxin, it must go through the reverse route as was described in
section II from the place of storage back to the external
environment.
Chemicals ard
transported from the place of storage mainly via the blood stream.
As the circulatory system leans itself toward the transport of water
soluble substances, the more lipophilic substances ard, the less
likely they are to freely diffuse into the blood and thus the
mobilization of these toxins from their place of storage is more
difficult. The same process as was discussed in section II, where
binding of toxins to carrier proteins and lipoproteins is the way
these toxins will enter the blood steam.
The toxins are thus
transported back to the organs of elimination, but if these organs
are dysfunctional, overloaded or damaged, the toxins cannot be
excreted. This means that such toxins will circulate further in the
blood stream and through diffusion enter some compartments again,
e.g. a fat soluble toxin may now be stored in the brain, with dire
consequences. The stimulation of toxins out of their compartments
should thus be a slow and careful process.
Here we distinguish
two groups of compartments:
1 The rapid-exchange
system
In these compartment,
tissue concentration of toxicant is similar to that of the blood
2 The slow-exchange
system
In these
compartments, tissue concentration of toxicant is higher than in
blood due to binding and accumulation-adipose tissue, skeleton and
kidneys can temporarily retain some toxins, e.g. arsenic and zinc.
The important fact is
that Detoxification and Drainage should carry on so long till the
slow exchange system is given a chance to give up all the toxins.
The organs involved in the Detoxification and Drainage of the toxins
will be discussed in the next section.
Conclusion
-
Toxins have to cross several membranes in the body to be
absorbed, and to eventually be stored, or eliminated via the
organs of elimination.
-
Toxins follow simple kinetics, and observe the diffusion over
semi-permeable membranes till a steady state is achieved on both
side of the membrane.
-
These basic kinetics are different for toxins who has a high
association co-efficient with proteins and cellular structures, be
it in the blood or in the organ of storage.
-
These kinetics affect both the storage and the mobilization of
toxins in and out of these compartments and needs to form the basis
on which the practical Detoxification and Dralinage is executed.
-
Two groups of compartments can be distinguished, depending on the
perfusion of the organ and the amount of toxin bound to protein.
- The
rapid-exchange system.
In
these compartments, tissue concentration of toxin is similar
to that of the blood.
- The slow-exchange system
In these compartments tissue concentration of toxin is higher than
in blood due to binding and accumulation.
- Many toxins are metabolized before they can get excreted.
One of the main purposes of this is to render fat soluble
toxins water soluble for excretion in the bile and kidneys.
- The P450 system of enzymes plays a major role here,
especially in the liver, where it comprises the phase I
reactions. This is augmented by the phase II reactions.
- Organs are at danger during the act of Detoxification and
Drainage, due to the high concentration of toxins moving
through the organ at the time, and through the generation of
free radicals during the detoxification process.
- Support of theses organs is thus of utmost importance during
detoxification and the elimination of the toxin.
 The
Organs of Detoxification and Elimination
As was seen in the
previous chapter, many organs and tissues are involved in the
absorption, the transport, the metabolism, the storage and the
delimination of toxins. These highly complex processes require
special properties of the organ to fulfill this function. Often, the
organ itself may be endangered by disease due to the excretion,
storage and movement of toxins through it.
We shall now consider
these organs in more depth.
1 The Liver
The liver is one of
the most important detoxifying and elimination organs in the body,
and metabolically the most complex. The liver is a major organ of
chemical elimination in that it takes up chemicals from blood,
metabolizes chemicals, and ensures the biliary and renal secretion
of toxins. The liver detoxifies a large array of external and
internal toxins. It also plays a role in the cholesterol metabolism,
glycolysis and gluconeogenesis, providing many of the plasma
proteins necessary for carrying hormones, fats and provides clotting
factors, to name a few of its numerous functions.
The principal cell in
the liver responsible for the detoxifying action is the hepatocyte
which facilitates the two pathways discussed in section II in
dealing with mainly fat soluble toxins in order to render them
hydrophilic or water soluble.
We have seen that
most toxins reach the organs of elimination via the blood stream.
The liver is very well perfused, and gets its blood from two sources
the arterial oxygen rich blood which is delivered through the
hepatic artery, and the venous blood through the portal vein from
which the liver gets all the blood that is shunted from the
capillaries of the gut and spleen.
Hepatocytes are
practically bathed in blood as this blood transverses a system of
sinusoids. This provides a very large surface for chemicals to
easily diffuse into the liver cells or hepatocytes. Due to the high
lipophilic character of many of the chemicals which are metabolized
by the liver, to be able to enter the water soluble area, they will
need carrier proteins. Several intracellular carrier proteins are
present in hepatocytes.
Once inside the
hepatocyte the chemical can interface with the phase I and II
enzymes to undergo biotranstormation and becom water soluble. A
number of these substances then diffuse back into the blood, where
they will be transported to the kidneys for elimination.
2 Excretion in
Bile
These bio-transformed
molecules can also diffuse over the membranes of the bile
canalilculus, and therefore flow into the bile duct. This is then
further delivered with the other constituents to the gallbladder
which excretes the bile into the intestine for fecal elimination.
In many instances we
also want to facilitate the drainage of bile. The gallbladder’s
primary function is to secrete bile and release it through the
cystic duct. This duct joins the hepatic duct from the liver to
create the common bile duct, which then empties into the upper part
of the small in testion, thus into the duodenum. Bile not only
carries away and neutralizes toxins, but it stimulates and aids
digestions by emulsifying fats, stimulating peristalsis, and acting
as a natural laxative.
3 Entero-hepatic
Circulation
This is a process
whereby already conjugated chemicals which are water soluble is
deconjugated by hydrolytic enzymes in the gut, and then redered
lipophilic again, and are once more reabsorbed by the gut. The liver
is thus exposed to another round of the same toxin to reprocess it
again and again, this increase the retention time for toxic
chemicals in the liver, and may increase liver boxicity. Some of
these metabolites are more dangerous than their original substance
and as we saw above, the P450 is also a source of free radicals
which will thus further damage the liver cell.
It is thus imperative
to protect the liver as well during the process of Detoxification
and Drainage. This will be further discussed in the section on
methods of detoxification.
4 The Kidneys
The kidneys are
organs specialized in the excretion of numerous water soluble toxins
and metabolites, maintaining homeostasis of the organism. The
kidneys detoxify
- Drugs
- Heavy metals
- Other toxins
Each kidney possesses
about one million nephrons able to perform excretion. Renal
excretion represents a very complex event encompassing three
different mechanisms:
- Glomerular
filtration by Bowman’s capsule
- Active transport in
the proximal tubule
- Passive transport
in the distal tubule
Blood is delivered to
the kidneys via the renal artery and about 625 ml of plasma move
through the kidneys per minute, and of that 125 ml is filtered
through the glomelular membrane. Most of the water is then
reabsorbed again in the proximal and distal tubule, so that only
approximately 1-2 liters of urine is formed per day.
Some filtered
substances, such as glucose will also be totally reabsorbed, so that
in normal conditions there is no glucose in the urine. Other
substances, many of which are harmful to the body are filtered,
secreted and then minimally reabsorbed. Creatinine is such a
substance, and can thus be used to test the efficiency of the
kidneys in clearing harmful substances. It accumulates in the blood
when the kidneys are dysfunctional. If the kidneys are damaged
through disease or toxins (drugs and chemicals), their ability to
excrete drugs is reduced, and in conventional medicine, the dose of
drugs in needs to be adjusted accordingly.
It is important for
the urine to be on the alkaline side, as it facilitates the
secretion of certain drugs, like barbiturates for instance, and
alkaline urine will prevent urinary tract infections.
The kidneys commonly
bear the brunt of chemical toxicity since the nephron tends to
concentrate the toxin and thus increase levels of toxic exposure in
the tubules.
The kidneys thus also
need protection and support throughout the Detoxification and
Drainage stages.
5 The Matrix and
Lymph
5.1 The Matrix
This forms the final
biophysical layer between the cell and the regulatory organs. This
system was largely forgotten since Virchow, a physician who worked
in Vienna and a contemporary of Freud, saw a cell through a
microscope and postulated that all diseases originated on a cellular
level. Another physician working there at the time, Rokitansky,
wanted to still bring in the humeral theory, but was largely
ignored.
Pischinger and Heine,
two modern researchers, brought this back into balance, and the
newer molecular biology texts increasingly recognize the role of the
matrix.
The cell on its own
is actually an abstraction. The cell does not come in contact with
the blood vessels, nerves, veins and lymph vessels which deliver
nutrients and messengers and remove toxins. It relies for this on
the biophyusical layer made up of highly polymerized sugar protein
complexes called Glycoaminoglycans(GAG’s) like hyaluronic acid,
chondroitin sulphate and heparin or when they are linked to a
protein backbone, they are called proteoglycans(PG’s). This
molecular sieve must be crossed by the entire array of metabolic
products.
Sugar protein
complexes are phylogenetically considered the best carriers of
information. Heine and Pischinger could show that if the matrix is
disturbed by a pin prick in one place, the disturbance is
communicated to the whole matrix in seconds. This makes it an ideal
system through which to give any information to the body. The
acupuncture point is an anatomical structure originating in the
matrix, a bell like structure, and it offers a wonderful ‘window’
into this system.
Unfortunately,
because of the chemical and electrical charges on the GAG’s and
PG’s, they also become the place where toxins are stored for a long
time.
The matrix is also
one of the tissues with a slow perfusion, and thus will have pattern
of slow turnover. The matrix has its own biorhythm, and is dependent
for instance on cortisol and thyroid hormone to be activated. During
the early hours of the morning, the body goes into an ebb phase with
a low cortisol, and it is during this ebb phase that the matrix will
purge itself from toxic materials. Stressed patients, or patients
who through a change in their sleepwake cycle have lifted or
disturbed the diurnal rhythm of cortisol, will not be able to
detoxify, as there may be a ‘misfiring’ between the matrix and the
liver. Cortisone in high doses as medication will also disturb the
innate rhythm of the body, and result in matrix toxicity. We can see
that in patients who has been on cortisone therapy, as the become
swollen and puffy in the matrix. Patients who are hypothyroid have
been described as having ‘myxoedema’ in the older textbooks. The
same swelling will be apparent in the matrix if the matrix biorhythm
is disturbed. May toxins are hydrophilic and will draw fluid into
the matrix. The result is edema, which we in clinical medi cine see
as cyclical edema in females or as cellulite.
It is clear from the
above that it the molecular sieve of the biophysical layer fails, is
polluted that there will be distortion of information to and from
the cell. If the disturbance is severe enough, cellular disease will
ensue.
Newer molecular
biological research shows that the matrix is the site for many
messengers which codes for intracellular phenomena, which, if
disturbed, can contribute to many disease phenomena, including
cancer. (Lukashev ME, Werb Z, 1998)
5.2 The Lymph
System
Apart from its role
in the immune system, the lymph system alse acts as a detoxifying
organ and drains most of the toxins from the matrix or connective
tissues via the lymph vessels, which finally drain into the superior
vena cave. The lymph system is made up of a myriad of little lymph
vessels which then aggregate into larger vessels. These larger
vessels are interspersed by aggregations of lymphoid tissue, which
are made up of immune competent cells. These lymph nodes, as the
aggregations are called, really function as super detection centers
for antigens, but it is also here whereto sensitized immune cells
will migrate in order to procuce millions of similar clones of that
sensitized cell. The migration is called “homing” in immunology and
the multiplication, cloning. The swelling we see in these lymph
nodes during an infection is due to the activation of the immune
cascade by these sensitized cells. This will cause an inflammation
of the lymph node.
A major portion of
our immune system is located in these lymph aggregations, and in
fact the largest part of our immune system is found in the gut
lining’s so-called Peyer’s paches. This is the reason why we can
manipulate the whole of the immune system by intervening on the
level of the gut lining.
Physiological
considerations
The lymph system is a
slow drainage system, and the propulsion of lymph towards the heart
is dependent on a number of factors. Firstly, the lymph vessels have
no valves, but depend on a sort of negative suction action of the
truncal vessels, which is similar to that of an amphibian heart. The
lymph flows relatively slowly at a rate of 1-2 ml/min, against a
high resistance, whereas the venous flow is rapid at 2-3 ml/min
against a low resistance. Two thirds of the body fluid is located in
the intracellular space, whilst a third is located in the
extra-cellular space. Of this, 75% is in the interstitial space or
connective tissue and about 25% circulates as plasma. The lymph and
venous flow is responsible for circulation most of the
extra-cellular fluid, and the interstitial fluid in particular is
drained mainly by the lymph system.
From the above it is
clear that the factors which will control the fluid interchange will
be:
- Oncotic pressure of
the plasma and the lymph is determined by the amount of
macromolecules such ass protein, and the electrolyte content such as
sodium, potassium, etc, in the solution. Solutes exert a certain
pressure in any fluid, as they ‘draw water’ so to speak and the more
there is of them in a solution, the higher the pressure. When a
patient is protein deficient for instance, through malnutrition or
disease, we see that there are not enough macremolecules to keep the
fluid in the vascular compartment, and the fluid will leak out into
the interstitium. The result is that the oncotic pressure in the
interstitium will exceed that of the plasma, and again edema will
ensue.
- The hydrostatic
pressure is a mechanical pressure, which can be compared to a hose
pipe connected to an open tap. The smaller the diameter of the hose
pipe, the higher the pressure, the more open the tap is, the higher
the pressure, and if there is an obstruction like a kink in the
hose, the higher the pressure before the kink, and the lower the
pressure after the kink. Fluid always tends to drain from a
high-pressure area to a low-pressure area over a semi permeable
membrane, which is represented by the venous capillary or the lymph
capillary, until the pressure is equal on both sides. Thhus if there
is obstruction in the venous system, similar to a kink in the hose,
there will be a high pressure in the vein, and the body will try to
equalize the pressure between the vein and the interstitium, thus
the fluid will also accumulate in the intrerstitium.
- If there is for
instance cardiac failure we see a back pressure into the venous
system, and in our hose model above, this will represent a wide open
tap, with more pressure in the venous system, and then more fluid in
the interstitium.
- Lastly if there is
an obstruction of the lymph flow, we will see a back pressure in the
lymph system and edema will again be the result. We see this in
diseases of the lymph vessels like Elephantiasis, where the lymph
vessel is scarred by a parasite for instance.
The lymph system as a
detoxifying organ
The lymph system has
a special relationship with the matrix. If is so to say as the only
way out for toxins which are stored in the matrix is via the lymph
system. It also means that if the matrix is overloaded with toxins
as well, as the lymph system has to remove the toxic debris out of
the interstitium, and at a certain point will also be clogged with
these. The stimulation of lymph flow is thus one of the most
important steps to achieve when cleaning the matrix.
6 The lungs
Not only does the
mucosa of the respiratory tract plays an important role as a barrier
to toxins as was discussed earlier, the lungs are also one of the
main points of excretion of gaseous and volatile drugs such as
anesthetics and even alcolol. Elimination via the lungs is typical
for toxins with high volatility (e.g.organic solvents). Gases and
vapours with low solubility in blood will be quickly eliminated this
way, whereas toxins with high blood solubility will be eliminated by
other routes.
Organic solvents
absorbed by the GIT or skin are excreted partially by exhaled air in
each passage of blood through the lungs, if they have a sufficient
vapour pressure. The breathalyzer test used for suspected drunk
drivers is based on the fact. The concentration of CO2
in exhaled air is in equilibrium with the CO2 – Hb blood
content. Another example is the radioactive gas radon which appears
in exhaled air due to the decay of radium accumulated in the
skeleton.
A number of toxins
and bacteria are also secreted in the mucous of the respiratory
tract, and expectoration is thus welcomed and supported.
7 The Mucosal
Membranes
Mucosal membranes
form the largest part of our bodies in contact with the outside
world, and they are therefore very specialized. Amucosal surface is
like a micro cosmos in itself, and a good example of all the
components of the auto regulatory system active in one organ. With
almost 80% of the immune system forming the mucosal associated
lymphoid tissue(MALT), some hormones having receptors on the mucosal
cells, a full complement of nerves mediated by the autonomic nervous
system, an active lymphatic drainage, and the large complement of
extra-cellular matrix, the mucosal membrane comprise one of the most
important regulatory organs. Not only does it form a very selective
barrier with the tight junction in between the epithelial cell and
adhesion molecules playing an important role in deciding what will
enter the body, mucosal surfaces can also let some of the immune
cells, like neutrophils through the tight junction to ingest toxic
material in the lumen. It further protects against toxins by
secreting chloride and other solutes tnto the lumen which will
osmotically draw water in order to wash away the offender, a fact
that we see as diarrhea in the gut for instance.
The integrity of
these surfaces is thus of major importance in the defense against
toxins.
The symbiotic gut
bacteria also need mentioning here as a barrier function. Not only
do they form a passive barrier against toxins coming in contact with
the epithelial surface, the also contribute to the defense against
toxins by producing certain metabolites which will serve as fuel for
the gut lining, and as such will then help the mucosal cell to keep
the integrity of the tight junction. However, due to the hydrolytic
enzymes produced by them, they can also contribute to the dangerous
entero-hepatic circulation mentioned above.
Absorption via gastrointestinal tract
Toxins can be
ingested in the case of accidental swallowing, intake of
contaminated food and drinks, or swallowing of particles cleared
from the respiratory tract.
In the case of toxins
biotransformed in the liver to less toxic or non-toxic metabolites,
ingestion may represent a less dangerous portal of entry. After
absorption in the GIT these toxins will be transported by the portal
vein to the liver, and there they can be partially detoxified by
biotransformation. The active area for absorption in the intestines
is about 100 m2.
Some toxic metal ions
use specialized transport systems for essential elements: Thalium,
cobalt and manganese use the iron system, while lead appears to use
the calcium system.
Many factors
influence the rate of absorption of toxins in various parts of the
GIT:
- Physico-chemical
properties of toxins, for example, particle size is important, the
smaller the size, the higher the solubility.
- Quantity of food
present in the gut (diluting effect).
- Residence time in
each part of the GIT (from a few minutes in the mouth to one hour in
the stomach to many hours in the intestines).
- The absorption area
and absorption capacity of the epithelium.
- Loca pH, which
governs absorption of dissociated toxins; in the acid pH of the
stomach, non-dissociated acidic compounds will be more quickly
absorbed.
- Peristalsis
(movement of intestines by muscles) and local blood flow.
- Gastric and
intestinal secretions transform toxins into more or less soluble
products; bile is an emulsifying agent producing more soluble
complexes(hydrotrophy).
- Combined exposure
to other toxins, which can produce synergistic or antagonistic
effects in absorption processes.
- Presence of
complexing/chelating agents.
- The action of micro
flora of the gut comprising about 1.5 kg made up of 60 different
bacterial species which can perform bio transformation of toxins.
When we thus detoxify
and drain, it is also imperative to support the actions of the gut,
but also to support the integrity of the barrier function in the
gut.
8 The Skin
The skin forms the
second largest surface of our body after the mucosa which is in
constant contact with the outside world. Apart from the barrier
function, it is also a major detoxifying organ, and has the same
P450 system seen in the liver, as well as glutathione to take care
of polycyclic aromatic hydrocarbons. The skin can absorbmany
substances (like pesticides and chemicals in cosmetic products), and
has to be able to detoxify them. Another important function of the
skin is to protect us against the harmful UV rays from the sun. The
glutathione and other free radical scavengers like catalase and
super oxide dismutase are of importance, as they scavenge the free
radicals formed by the UV ray exposure. Like in the liver though,
induction of the detoxifying P450 pathway will also generate free
radicals so that in the presence of toxins the skin is more exposed
to the effects of free radicals, which leads to immunotoxicity,
tissue destruction and eventually skin ageing as wekk as cabcer.
Conversely, UV rays damage the detoxifying ability of the skin (the
P450), and sun dam aged skin is thus less able to deal with toxins.
Due to its role in
detoxification, and being one of our most important excretory
organs(through sweat and evaporation), we also see the skin often
bearing the brunt when other detoxifying organs like the liver are
overloaded. Eczema, drug induced rashes and increased sweating are
examples of this. In these cases it is thus important to support
other organs like the liver for detoxification in skin disease. The
liver and skin for instance break down histamine in the body through
the P450. If the systems are overloaded, allergy will ensue.
Histamine and other amines are also formed during the inflammatory
process, and many environmental toxins, like alcoholic drinks,
especially red wine can contain a large amount of histamine.
9 Sweat
Many non-electrolytes
can be partially eliminated via skin by sweat, ethyl alcohol,
acetone, phenols, carbon disulphide and chlorinated hydrocarbons.
10 Hair
Analysis of hair can
be used as an indicator of homeostasis of some physiological
substances. Also exposure to some toxins, especially heavy metals,
can be evaluated by this kind of bioassay.
11 Other Routes of
Elimination
Milk
Many metals, organic
solvents and some organocholrine pesticides(DDT) are secreted via
the mammary gland in mother’s milk. This pathway can represent a
danger for nursing infants.
Saliva
Some drugs and
metallic ions can be excreted through the mucosa of the mouth by
saliva, for example, lead(“lead line”), mercury, arsenic, copper, as
well as bromides, iodides, ethyl alcohol, alkaloids, and so on. The
toxins are then swallowed, reaching the GIT, where they can be
reabsorbed or eliminated by feces.
Conclusion
- Many organs are
involved in the storage, metabolism and elimination of toxins once
the toxin is absorbed into the body.
- The liver is one of
the major detoxification organs, and plays an especially important
role in the processing of toxins being absorbed via the oral route.
- The liver is well
perfused and also equipped with enzymes to render fat soluble toxins
to water soluble toxins to be excreted in the kidney and bile.
- The kidney deals
with the above mentioned water soluble toxins, but is also the major
organ of elimination dealing with heavy metals and several drugs.
- The lung play a
major role in the elimination of volatile gases, e.g. organic
solvents and gases and vapours with high solubility in the blood.
- The mucous
membranes act as a barrier, but also contain the P450 system of
enzymes and can actively metabolize and excrete toxins.
- The symbiotic micro
flora plays a special important role here.
- Sweat, hair, milk
and saliva are minor elimination organs, and can be used to test the
elimination of toxins such as heavy metals and other toxins.
- Excretion of toxins
in milk pose a risk to the infant.
- The matrix and also
with it the adipose tissue form a major site of deposition of both
water and fat soluble toxins, and due to the fact that this is a
slow exchange compartment and in close association with the cell, is
a major area of concern in chronic intoxication.
- The lymph system is
the only significant way toxins can be drained from this compartment
and therefore needs special attention during the drainage process.
RN13( NeyGeront )
General Description
RN13 is designed
specifically to treat premature aging and geriatric complaints. It
acts on cell respiration and metabolism in organs which are
particularly affected by aging, RN13 contains 13 different animal
source RNAs, as well as vitamins, amino acids, procaine and glutamic
acid and biolecithin to improve cerebral activity. In the body, RNA
is responsible for protein biosynthesis, helping to repair and
regenerate body tissues and organs, RN13 purports to work on the
principle that animal source RNAs from specific organs may stimulate
the same organs in humans. RN13 has been shown to make aging
individuals more alert and vital and to improve weak concentration,
defective memory, anxiety, troubled sleep and lack of appetite.
Role for Anti-Aging
RN13’s anti-aging
benefits may include prevention and treatment of premature aging and
many types of age-related disorders, lifting of apathy and potential
increase in lifespan.
Side
Effects/Contraindication
Side effects are rare
but may include mild irritation at the site of an injection and
minor allergic reactions such as a skin rash. People suffering
disturbances in purine metabolism, should avoid RN13 therapy
Antibiotics and drugs that suppress the immune system may inhibit
RN13’s efficacy.
Pharmacology
A multi-combination
product, of which each capsule contains macromolecular organ
substances out of embryo 0.37 ng, placenta 0.1 ng, amnion 6-pg,
funiculus umbilical 60 pg, parathyroid 20 pg, testes juv. And fet.
0.2ng; as well as mixture of the following drug additives; heparin
5x10-3 IU, L-glutamic acid 10ug, methenolone acetate 4ng, trijod
thyroxin HCL 4pg, vitamin E 40ng, vitamin B12 40ng, vitamin B6 40ng,
p-aminobenzoyldiethylaminoethanol HCL (Procaine) 5ng, biolecithin
10mg, trace elements (Fe, Co, Cu, Mg, Zn, Ca) 1.5ng, sodium dodecyl
sulfate 15ug, medium chained triglyceride 410mg.
Distribution ; RN13
is administered by injection and supplemented by ampules or
capsules.
VitOrgan of Germany
manufactures RN13 under the trade name NeyGeront®.
Desiccated Glandular
Products and RNA Supplementation
By Phil Micans PharmB
This article is a
synopsis of glandular therapies and treatments that have been a
basis of German alternative medicine for a number of years. It is
designed to introduce the use of desiccated glandular products and
RNA (ribonucleic acid) supplementation (trade name RN13 or NeyGeront®).
The main clinical studies are based upon Lachnit, Klausner,
Proszowski and Rieder’s work entitled Ageing and Disease, A
Macromolecular Problem?
Human Ecosystem
The desire for health
is a basic component of daily language. The German word “Gesundheit”
used when someone sneezes means “health”. We wish each other good
health on birthdays, for the New Year and many other festive
occasions. We are even concerned with our physical well being when
we raise a glass to propose a toast, with words such as prost or
cheers.
But things such as
the Chernobyl accident, the dying of forests, the ozone gap,
climatic catastrophes, the air pollution and pesticides etc are all
phenomena of our times that endanger our health. Along with the
“Eco-System Earth,” the open system of the “Human Ecosystem” can
also lose its balance as well.
Like all Eco-Systems,
the human being achieves stability through the harmonious
co-operation of multiple factors. We ard all aware that if the
elements air and water are disturbed, plants can no longer live,
herbivores can no longer find food and carnivores must then die. The
same situation applies to the Human Ecosystem. The repair of
individual damaged organs does little good when the organic entirety
has to be fortified in its resistance.
Biomolecular Therapy
or BT (consisiting primarily of glandular and RNA Therapy) is a
treatment that helps maintain the harmonious co-operation of the
Human Ecosystem. The molecular building blocks of nature affect each
and every individual cell, they are the basic building blocks of
each organism.
The cell is the
smallest, and, at the same time, the most elementary building block
in the Human Ecosystem.
The advantage of BT
is that it not only serves to cure existing health defects but it is
also suitable for the prevention of illness. And prevention is
necessary, for whenever we encounter the so-called routine
“complaints” such as; stomach-ache, head-ache, sleeplessness,
dysfunction’s of the appetite, or fatigue, the alarm system of the
Human Ecosystem has been triggered. We may compare the Human
Ecosystem to a mountain lake. Its well balanced ability to function
is determined by many factors; the ideal composition of the water,
the adequate organisms from fauna and flora, the oxygen content, the
nitrogen content and other individual elements.
Once we introduce
pollutants into the lake e.g. waste water or oil, the lake becomes
turbid. However, it will use its defense mechanism in order to
destroy these elements, and eventually it can recuperate. However,
if the limit of pollutants is exceeded, the lake’s defense systems
become fundamentally damaged, and thus the entire balance is
overthrown.
In the same way there
is a need to strive toward the intact Human Ecosystem. Indeed, we
have to act not only to repair but essentially to take precautions
and to exercise precaution. Thus, if we can maintain our own
Ecosystem and increase our functional capacity, we will boost the
activity of individual organs and organic systems as well as
increasing witality. The idea behind BT is simple: Biomolecular
Therapy utilizes the composition of natural biomolecules for
treatment. These building blocks are combined according to the
symptoms, the organism receives exactly what it needs and as a
result, the Human Ecosystem retains its harmonious balance.
More than 35 years of
research and applications of the BT on a national(Germany) and
international basis have demonstrated the high efficacy of this type
of therapy, both in children and adults.
With advancing age,
the metabolic activities of the different organic systems become
increasingly more sluggish. The elementary building blocks of BT
revitalize the metabolism and consequently eliminate any deficiency
symptoms, just like they normalize the attrition which aging bodies
experience but cannot combat from within.
One of the theories
of aging is based upon the organism’s gradual loss of ability to
divide itself. During the course of a human life, a cell divides
about 40-50 times, thereby taking care of the continuous renewal of
the total organism.
With BT, the rate of
cell division can be increased by 20%. A higher activity of division
means; more vitality, more mental flexibility, a higher quality of
life and therefore a better enjoyment of life in old age.
If you are
experiencing numerous symptoms and illnesses of various organs or
such symptoms are present, you should consider therapy with BT.
Such an elementary
holistic approach makes possible virtually unlimited applications.
Most BT revitalization therapies (such as RN13) are used mainly for
prevention, whereas other forms of BT glandular therapies, can treat
specific diseases either in isolation, or in combination with
medications.
Biomolecular Therapy
can naturally harmonize the Human Ecosystem and therefore help to
eliminate various disturbances in the individual’s system.
Biomolecular
Principles and History
Most disease of man
and animals are accompanied by particular morphologican and
molecular cell changes, some of which are so specific that it its
actually impossible to reach a diagnosisi from histological samples
alone.
Clinical chemistry
also provides pointers to very specific cell defects. It seems a
logical step to reverse these cell defects by supplying the body
with the relevant components taken from healthy cells, so that the
diseased organs can function properly again. This goes hand in hand
with repair and renewal.
The therapeutic
concept of providing sick organs with elements taken from identical
healthy organs is not new. It can be traced back to the days of
antiquity and also embraces Niehans’ cell therapy and organ lysate
therapy.
Theurer indicated the
principle of Biomolecular Therapy (BT) in the early fifties. Theurer
was also responsible for endowing this principle with immunological
flexibility, thus making it absolutely safe. Theurer realized right
from the start that the therapeutic efficacy of organ preparations
must be linked to their molecular components; proteins, peptides,
lipids and polysaccharides. The nature of the internationally
patented method of preparation, the holistic application, and the
individual dose titration set this therapy apart from other organ
extrac and cell therapy techniques.
BT makes use of
natural regulatory and metabolic substances which are similar in
animals and man. Impaired regulatory processes are normalized by
physiological means, providing causative support for the recovery
process.
The supporting
experimental literature from leading universities, institutes and
clinics all over the world is vast and there are countless reports
of success in human and veterinary practice.
It is precisely the
causative effect which draws BT so close to the philosophy of the
naturopath. Its rule is not to concentrate on curing the symptoms,
but to see the body as a whole and to treat its entirety.
That is why BT does
not use just one type of organ, e.g. thymus (which is, of course,
very important), but also employs factors from other organs.
Monotherapy (with one factor only), cannot do justice to the
principle of holistic medicine because pathophysiologica processes
are interwoven with the complexity of cybernetic principles.
Using molecular
extracts from healthy tissue for holistic therapy in accordance with
immunological and allergic principles means “treating the cause, not
just the symptoms.”
Biomolecular Therapy
Specifically designed
for geriatric disorders, the Biomolecular Therapy of RN13 (which is
also known as NeyGeront® is a unique combination of
macromolecular organo-specific cell extracts from selected healthy
young animals and animal fetuses. It is supported by mucleic acids,
proteins, polysaccharides and lipids including their molecular
subunits and cellular energy transmitters.
A special cell
processing technique was developed so that the presentation forms a
soluble agent in the small intestine, this is in order to ensure the
bioavailability of the cell elements administered.
RN13 also contains
cell constituents of fresh organ tissues equivalent to those organs
most frequently affected by the symptoms of stress, wear and aging
like the heart, thymus, gonads, liver, pancreas and other glands,
including the mucous membranes and spleen, Furthermore it contains
cell factors of total foetus, placenta, amnion and umbilical cored,
which have a revitalizing effect on the entire organism. The
efficacy of these macromolecular cell extracts have been
demonstrated in human cell cultures and confirmed statistically by
the results of treatment in patients.
In addition, the
carriedr effect of these organo-specific cell elements is utilized
in order to achieve a direct supply of vitamin complexes consisting
of vitamins B6m B12 and E, as well as the agents biolecthins,
procaine and trace elements for organs showing signs of exhaustion.
The action of RN13 is
therefore based on a two-fold therapeutic mechanism; first, on
macromolecules supporting the regeneration and normalization of cell
functions and second, on tonics, vitamin complexes, amino acids and
biolecthins that have an improving effect, in particular on cerebral
activity and deficient cellular metabolism.
RN13 is therefore
recommended for all the following states; general revitalization,
premature aging, states of physical and mental exhaustion, defective
memory, disturbed potency arteriosclerosis, slow convalescence,
difficulty in falling asleep, disturbed development and growth.
The RN13 capsules
should be taken one in the morning and another in the early
afternoon.
Neydin salve®
Applications
Neydin salve is an
ideal food supplement concentrated from the placenta, embryo,
amnion, funiculus umbilicalis.
It is widely used for
life extension and increased sex drive, by stimulating the body
grown own production of spermatozoids, and to bring back all of the
important rejuvenating hormones, like testosterone, estrogens,
progesterone and many more, to a level of a young adolescent.
Neydin salve can be
seen as “the poor man’s “ “Cell Therapy” It keeps you young, fit and
energetic. Makes your skin soft and smooth, repairs pimples and
other impurities, and gives improved sex life for both sexes.
Many more indications
in which Neydin salve works well, likt the prevention an treatment
of osteoporosis(bone decalcification during menopause and in elderly
people) and can replace hormone treatment in women.
It promotes the
healing of wounds, speeds up recovery after serious operations and
is successfully used in anemia of any origin. The amino acids in
Neydin salve slow down the aging process and mental retardation and
they improve the memory. They produce proteins and oxygen and
therefore have a positive effect on cell metabolism. The tone of the
skin is improved, hair growth is stimulated and nails become less
porous.
Moreover, Neydin
salve is used in the case of work or sports which demand a high
level of physical exertion and in the case of sexual apathy. Some
amino acids are known to be good for the defense system and the
stimulation of sperm production. Some amino acids stimulate the
production of growth hormones, hormones described peviously, which
keep a person young. Natural growth hormones decrease as we get
older. Around the age of 50 the production stops completely. But
with a supplement of amino acids and multivitamins in the right
proportion the production of this rejuvenating hormone can be
brought back to the level of young adults.
The composition of
Neydin salve is based exclusively on those substances which the
placenta, the source of life, produces. Nothing is added.
The benefit and use
of these capsules can be briefly summarized as follows:
Calcium
80% of all women have
a calcium deficiency. To be able to absorb calcium from calcium
tablets, the body has to have sufficient vitamin D. The daily
requirement of chemical or foreign calcium is between 800 and 1,200
miligram. The absorption of chemical calcium is mediocre and, if the
calcium is taken from bone meal, it contains far too much lead.
The concentration of
natural calcium in Neydin salve is sufficient, combined with a good
multivitamin, to prevent and to treat osteoporosis.
Iron
The human iron
produced by the placenta is also completely reabsorbed, whereas
normally only 8% of all the iron taken in food or food supplements
ends up in the blood. Iron increases our resistance, prevents
tiredness, promotes growth, remedies anaemia and gives the skin a
good tone.
Phosphorus
This is present in
every body cell and functions only if there is sufficient vitamin D
and calcium. We need phosphorus for normal bone and tooth growth. It
produces energy, helps convert fat and starch, reduces pain from
arthritis and is good for teeth and gums. The biological phosphorus
in Neydin salve is sufficient to supply the daily human requirement
of this mineral.
Copper
This is needed to
convert iron into haemoglobin, it promotes the effect of
tyrosine(the pigment factor for hair and skin) and is essential for
the absorption of vitamin C. It produces energy as it promotes the
absorption of iron.
Zinc
This mineral
maintains the enzyme system and the cells and is needed to produce
proteins and insulin. It has a favorable effect on the prostate, the
production of sperm and brain functions. There is recent evidence
that zinc is needed to produce DNA, the main component of
chromosomes.
Vitamin B2
Otherwise known as
Riboflavin. This helps growth and reproduction, gives healthy skin,
nails and hair, remedies a dry mouth, improves eyesight and promotes
the metabolism of carbohydrates, fat and proteins. Women who are
taking the pill, are pregnant or are breast-feeding need increased
amounts of vitamin B2.
Amino acids
The amino acids in
Neydim salve are autologous. The concentration and the ratio are
completely physiological, i.e. exactly as the placenta produces
them. Some amino acids are not produced by the placenta as certain
enzymes needed for this are lacking.
The amino acids in
Neydin salve are at least as important as vitamins, are materials
for proteins, the most important nutrient, and can stop the
degeneration process. Every cell in our bodies contains proteins and
needs these to produce new tissue and repair damaged materials.
The placenta produces
hormones in our body (including the anti-aging growth hormone) as
well as HSG, HPL, HCT and HCC, which raise the concentration of ACTH
and DHEA in the blood, and thus contribute to maintaining your
“Quality of Life”.
The ex-organ also
produces enzymes, retains the balance of the acid/base in the blood
and removes waste substances. Proteins are broken down into smaller
pieces; amino acids. When these amino acids reach the cells in the
body, they are converted back into proteins. Knowledge of this
wonderful cycle has resulted in a growing demand for good food
supplements with amino acids.
The various
properties of these substances, which are also important
genetically, are summarized as follows;
Analine
Strengthens
resistance, reduces the chance of kidney stones and helps combat
tiredness as a result of too low a glucose content in the blood.
Arginine
Produces growth
hormones, increases the sperm count and the quality of the sperm,
strengthens the immune system and speeds up the healing of wounds.
Breaks down body fat and strengthens the muscles. Increases physical
and mental alertness.
Asparagine acid
Strengthens
resistance, increases stamina and removes harmful ammonia.
Phenylalanine
Combats depression,
suppresses feelings of hunger and sometimes acts as a natural
painkiller.
Glutamine acid
Improves brain
functions, remedies tiredness and promotes the healing of wounds.
Glycine
Good for the muscles,
blood and reduces too high acidity of the stomach. Helpful in the
case of a sluggish hypophysis function.
Histidine
Helps in the case of
rheumatoid arthritis and stress and raises the libido.
Lysine
Increase the ability
to concentrate, raises fertility and can help prevent herpes simplex
infections.
Methiodine
Lowers cholesterol
levels, helps in the treatment of schizophrenia and
Parkinson’s disease
and reduces the chance of cancer.
Serine
Pain-killer and has a
natural anti-psychotic effect.
Theonine
Needed for the
absorption of proteins via food.
Tryptophan
Reduces feelings of
fear, promotes sleep and is used to treat alcoholism and as a
natural painkiller.
Tyrosine
Helps in the case of
sexual apathy and stress and suppresses feelings of hunger.
Valine
Natural anabolic
muscle strengthener, converts fat into muscle.
Biogenic stimulants
and Biomolecular Therapy
Discovered by Prof.
Niehans and occurring as a reaction to “life-threatening
circumstances” by living tissue in order to be able to survive. It
is the basis of cell therapy according to Prof. Niehans and plays a
central role in life-extension therapies. As yet nowhere near
everything is known about biogenic stimulants. They are thermostable,
contain growth factors in addition to ribonucleic acids and are
capable of making the body produce all sorts of important
rejuvenating hormones naturally. The placenta, as an autologous
basis, is the ideal source for the production of biogenic stimulants
for a universal anti-aging effect on the whole body.
Contents
Neydin salve contains
in mixture of standardized biomolecular regulation factors of animal
origin.
One Neydin salve
capsule contains : Embryo tot.594 mg, Placenta 240 mg, Amnion 180
mg, Funiculus umbilicalis 180 mg, Heparin 5x10(-3) IE, L-Glutamic
acid 10 mg, Metenolonacetate 4.0 ng, Procain-HCL 8.00 ng,
Biolecithin 10 mg, Trace minerals(Fe, Co, Cu, Mg, Zn, Ca) 1.50 ng,
Nadodecylsulfat 15 mcg, Triglycerides 410 mg
Indication :
Premature aging, impotence, age related diseases, skin rejuvenation
Dosage : Neydin salve
capsules are taken once to twice daily half an hour before meals.
Side effects : There
ard usually no side effects.
|
Face
